CRC Transregio 221|Projects

Project IRTG

 

Integrated Research Training Group of the CRC/TR221.

Principal Investigators: Prof. Dr. med. Matthias Edinger, PD Dr. med. Anita Kremer, PD Dr. rer. nat. Friederike Berberich-Siebelt

Summary Project IRTG

The Integrated Research Training Group (IRTG) of the CRC/TR 221 supports the participating MDs and PhD students of the program by providing well-structured and interdisciplinary training and qualification modules. The program focusses on basic and translational science in the area of allogeneic hematopoietic stem cell transplantation and cell therapy, but covers all topics and technologies of current biomedical research. Through close supervision and mentoring programs the students are well supported for a successful graduation in an innovative research field.

 

Contact to Principal Investigators

Prof. Dr. Matthias Edinger

                        

PD Dr. Anita Kremer

                     

PD Dr. Friederike Berberich-Siebelt

University Hospital Regensburg

 

University Hospital Erlangen

 

University Würzburg

Department of Internal Medicine III

 

Department of Medicine 5

 

Institute for Pathology

Franz-Josef-Strauß-Allee 11

 

Ulmenweg 18

 

Josef-Schneider-Str. 2

93053 Regensburg

 

91054 Erlangen

 

97080 Würzburg

T: +49 941 944-5580

 

T: +49 9131 85-43183

 

T: +49 931 3181208

matthias.edinger(at)ukr.de

  anita.kremer(at)uk-erlangen.de   path230@mail.uni-wuerzburg.de

Project INF

 

Data integration platform and systems medicine efforts to foster GvL and GvHD research

Principal Investigator: Prof. Dr. med. Thomas Dandekar, Prof. Dr. med. Ernst Holler, Prof. Dr. rer. nat. Birte Kehr, Dr. rer. nat. Meik Kunz

Site: Regensburg, Erlangen, Würzburg

Project INF

The INF project represents the data infrastructure project. It focuses mainly on data   management and sustained storage of all publication relevant scientific data. We also support the individual projects with adequate software and expert knowledge during the entire data analysis process. Our long-term aim is that the increasing amount of research data generated by the numerous immunologists, physicians and other scientists at the TR 221 sites Regensburg, Erlangen and Würzburg ultimately help to find new ways and tools that make allogeneic hematopoietic stem cell transplantation a more safe and effective treatment procedure, particularly by reducing transplant complications and relapse rates in patients. The INF project is financed during the first funding period by funds from the free state of Bavaria.

 

Contact to Principal Investigator

Prof. Dr. med. Thomas Dandekar

      Prof. Dr. med. Ernst Holler

      Prof. Dr. rer. nat. Birte Kehr

Dr. rer. nat. Meik Kunz

Julius-Maximilians-Universität Würzburg

      University Hospital Regensburg

     LIT - Leibniz Institute for Immunotherapy (former RCI)      

FAU Erlangen-Nürnberg

Lehrstuhl für Bioinformatik

      Department of Internal Medicine III

     c/o Universitätsklinikum Regensburg

Wetterkreuz 15

Am Hubland

      Franz-Josef-Strauss-Allee 11

     Franz-Josef-Strauß-Allee 11

91058 Erlangen

97074 Würzburg

      93053 Regensburg

     93053 Regensburg

T: +49 9131 8567784  

T: +49 931 318 4550

      T: +49 941 943 5935

     T: +49 941 944 18161

meik.kunz(at)fau.de

dandekar(at)biozentrum.uni-wuerzburg.de

      ernst.holler(at)ukr.de

     birte.kehr(at)ukr.de

 

Project Z01

 

Pathology work-up of GvL and GvHD in mice and men.

Principal Investigators: Prof. Dr. med. Matthias Evert, Prof. Dr. med. Maike Büttner-Herold, Prof. Dr. med. Andreas Rosenwald

Summary Project Z01

GvHD diagnosis is still a challenge even for experienced transplant pathologists due to its variable clinical and histological manifestation and the still insufficient validity and reproducibility of diagnostic histopathological criteria. In this service project, expert (immuno-)histological evaluation of human and murine tissues is provided. Furthermore, a digital histology archive will be established that includes consensus reports generated in virtual microscopy conferences and that are linked to clinical data bases for the evaluation of transplant outcome, complications and prognostic histology biomarkers.

 

Contact to Principal Investigators

Prof. Dr. Matthias Evert

                        

Prof. Dr. med. Maike Büttner-Herold

                     

Prof. Dr. med. Andreas Rosenwald

University Regensburg

 

University Hospital Erlangen

 

Julius-Maximilians-University Würzburg

Department of Pathology

 

Department of Nephropathology

 

Department of Pathology

Franz-Josef-Strauß-Allee 11

 

Krankenhausstraße 8-10

 

Josef-Schneider-Str. 2

93053 Regensburg

 

91054 Erlangen

 

97080 Würzburg

T: +49 941 944-6600

 

T: +49 9131 85-22605

 

T: +49 931 31-81199

matthias.evert(at)ukr.de

 

maike.buettner(at)uk-erlangen.de

 

rosenwald(at)uni-wuerzburg.de

Project Z02

 

Animal engineering and complex transplantation models.

Principal Investigators: PD Dr. rer. nat. Petra Hoffmann, Prof. Dr. rer. nat. Thomas Winkler, Prof. Dr. med. Dr. med. univ. Andreas Beilhack

Summary Project Z02

Due to the complexity of graft-versus-host (GvH) and graft-versus-leukemia (GvL) reactions their basic biology as well as novel intervention strategies can only be examined in adequate preclinical in vivo models. In addition to providing general support in all experimental and regulatory issues, the Z02 service project will generate valuable new genetically modified mouse strains for the consortium and provide an experimental platform permitting the investigation of GvHD in germ-free and gnotobiotic mice. We aim for highly informative, cross-validated, reproducible and predictive in vivo models at the three participating centers.

 

Contact to Principal Investigators

PD Dr. rer. nat. Petra Hoffmann

                        

Prof. Dr. rer. nat. Thomas Winkler

                    

Prof. Dr. med. Dr. med. univ. Andreas Beilhack

University Hospital Regensburg

 

FAU Erlangen-Nürnberg

 

University Hospital Würzburg

Department of Internal Medicine III

 

Department of Biology

 

Department of Medicine II

LIT - Leibniz Institute for Immunotherapy (former RCI)

 

Nikolaus-Fiebiger-Center for Molecular Medicine

 

ZEMM Center for Experimental Molecular Medicine

Franz-Josef-Strauß-Allee 11

 

Glückstraße 6

 

Zinklesweg 10

93053 Regensburg

 

91054 Erlangen

 

97078 Würzburg

T: +49 941 944-5592

 

T: +49 9131 85-29136

 

T: +49 931 201-44040

petra.hoffmann(at)ukr.de

 

thomas.winkler(at)fau.de

 

beilhack_a(at)ukw.de

Project Z03

 

Central administration of the SFB Transregio 221

Principal Investigator: Prof. Dr. med. Wolfgang Herr

Summary Project Z03

The central administrative project takes care of the administrative and organizational matters of the CRC/TR 221. It manages the funds that are primarily used for the (i) recruitment and early career support of excellent young postdocs, (ii) rotation („Gerok“) positions for clinical principal investigators and young MD scientists, (iii) gender equality measures, (iv) support of new projects that have the potential to advance the CRC/TR program, (v) establishment and maintenance of a central biomaterial repository, (vi) project-specific workshops and guest speaker seminars, (vii)  traveling, (viii) public relation work.

 

Contact to Principal Investigator

Prof. Dr. med. Wolfgang Herr

University Hospital Regensburg

Department of Internal Medicine III

Franz-Josef-Strauß-Allee 11

93053 Regensburg

T: +49 941 941-5501

wolfgang.herr(at)ukr.de