The Integrated Research Training Group (IRTG) of the CRC/TR 221 supports the participating MDs and PhD students of the program by providing well-structured and interdisciplinary training and qualification modules. The program focusses on basic and translational science in the area of allogeneic hematopoietic stem cell transplantation and cell therapy, but covers all topics and technologies of current biomedical research. Through close supervision and mentoring programs the students are well supported for a successful graduation in an innovative research field.
Prof. Dr. Matthias Edinger |
| PD Dr. Anita Kremer |
| PD Dr. Friederike Berberich-Siebelt |
University Hospital Regensburg | University Hospital Erlangen | University Würzburg | ||
Department of Internal Medicine III | Department of Medicine 5 | Institute for Pathology | ||
Franz-Josef-Strauß-Allee 11 | Ulmenweg 18 | Josef-Schneider-Str. 2 | ||
93053 Regensburg | 91054 Erlangen | 97080 Würzburg | ||
T: +49 941 944-5580 | T: +49 9131 85-43183 | T: +49 931 3181208 | ||
anita.kremer(at)uk-erlangen.de | path230@mail.uni-wuerzburg.de |
The INF project represents the data infrastructure project. It focuses mainly on data management and sustained storage of all publication relevant scientific data. We also support the individual projects with adequate software and expert knowledge during the entire data analysis process. Our long-term aim is that the increasing amount of research data generated by the numerous immunologists, physicians and other scientists at the TR 221 sites Regensburg, Erlangen and Würzburg ultimately help to find new ways and tools that make allogeneic hematopoietic stem cell transplantation a more safe and effective treatment procedure, particularly by reducing transplant complications and relapse rates in patients. The INF project is financed during the first funding period by funds from the free state of Bavaria.
Prof. Dr. med. Thomas Dandekar | Prof. Dr. med. Ernst Holler | Prof. Dr. rer. nat. Birte Kehr | Dr. rer. nat. Meik Kunz | |
Julius-Maximilians-Universität Würzburg | University Hospital Regensburg | LIT - Leibniz Institute for Immunotherapy (former RCI) | FAU Erlangen-Nürnberg | |
Lehrstuhl für Bioinformatik | Department of Internal Medicine III | c/o Universitätsklinikum Regensburg | Wetterkreuz 15 | |
Am Hubland | Franz-Josef-Strauss-Allee 11 | Franz-Josef-Strauß-Allee 11 | 91058 Erlangen | |
97074 Würzburg | 93053 Regensburg | 93053 Regensburg | T: +49 9131 8567784 | |
T: +49 931 318 4550 | T: +49 941 943 5935 | T: +49 941 944 18161 | ||
GvHD diagnosis is still a challenge even for experienced transplant pathologists due to its variable clinical and histological manifestation and the still insufficient validity and reproducibility of diagnostic histopathological criteria. In this service project, expert (immuno-)histological evaluation of human and murine tissues is provided. Furthermore, a digital histology archive will be established that includes consensus reports generated in virtual microscopy conferences and that are linked to clinical data bases for the evaluation of transplant outcome, complications and prognostic histology biomarkers.
Prof. Dr. Matthias Evert |
| Prof. Dr. med. Maike Büttner-Herold |
| Prof. Dr. med. Andreas Rosenwald |
University Regensburg | University Hospital Erlangen | Julius-Maximilians-University Würzburg | ||
Department of Pathology | Department of Nephropathology | Department of Pathology | ||
Franz-Josef-Strauß-Allee 11 | Krankenhausstraße 8-10 | Josef-Schneider-Str. 2 | ||
93053 Regensburg | 91054 Erlangen | 97080 Würzburg | ||
T: +49 941 944-6600 | T: +49 9131 85-22605 | T: +49 931 31-81199 | ||
Due to the complexity of graft-versus-host (GvH) and graft-versus-leukemia (GvL) reactions their basic biology as well as novel intervention strategies can only be examined in adequate preclinical in vivo models. In addition to providing general support in all experimental and regulatory issues, the Z02 service project will generate valuable new genetically modified mouse strains for the consortium and provide an experimental platform permitting the investigation of GvHD in germ-free and gnotobiotic mice. We aim for highly informative, cross-validated, reproducible and predictive in vivo models at the three participating centers.
PD Dr. rer. nat. Petra Hoffmann |
| Prof. Dr. rer. nat. Thomas Winkler |
| Prof. Dr. med. Dr. med. univ. Andreas Beilhack |
University Hospital Regensburg | FAU Erlangen-Nürnberg | University Hospital Würzburg | ||
Department of Internal Medicine III | Department of Biology | Department of Medicine II | ||
LIT - Leibniz Institute for Immunotherapy (former RCI) | Nikolaus-Fiebiger-Center for Molecular Medicine | ZEMM Center for Experimental Molecular Medicine | ||
Franz-Josef-Strauß-Allee 11 | Glückstraße 6 | Zinklesweg 10 | ||
93053 Regensburg | 91054 Erlangen | 97078 Würzburg | ||
T: +49 941 944-5592 | T: +49 9131 85-29136 | T: +49 931 201-44040 | ||
The central administrative project takes care of the administrative and organizational matters of the CRC/TR 221. It manages the funds that are primarily used for the (i) recruitment and early career support of excellent young postdocs, (ii) rotation („Gerok“) positions for clinical principal investigators and young MD scientists, (iii) gender equality measures, (iv) support of new projects that have the potential to advance the CRC/TR program, (v) establishment and maintenance of a central biomaterial repository, (vi) project-specific workshops and guest speaker seminars, (vii) traveling, (viii) public relation work.
Prof. Dr. med. Wolfgang Herr |
University Hospital Regensburg |
Department of Internal Medicine III |
Franz-Josef-Strauß-Allee 11 |
93053 Regensburg |
T: +49 941 941-5501 |